The human beings, together with their cultures and lifestyles, are facing unprecedented threat from fundamental change of the global climate system. The change is caused by rapid growth of greenhouse gases from primarily fossil fuel use. Carbon neutrality, or zero emission of carbon and other greenhouse gases, is essential to sustaining the socio-economic development and civilization. The Thrust of Carbon Neutrality and Climate Change (CNCC) is conceived to address the greatest challenge of our age, while seizing the greatest opportunity for prosperity and sustainability of the society. The cross-disciplinary program covers carbon science and technology, climate change and governance, sustainable energy transition, and eco-civilization and green development. CNCC thrust is designed to train the next generation of leaders through knowledge creation, creative thinking and problem-solving, and hands-on real world practices. In keeping abreast with the mission, CNCC Thrust will strive to embrace the global trend to meet the need of the society and to benchmark with programs worldwide.